The Science Behind Our Products

Rejuran® uses c-PDRN® to encourage dramatic age-defying results for more radiant, youthful looking skin.

The Science Behind Our Products

Rejuran® uses c-PDRN® to encourage dramatic age-defying results for more radiant, youthful looking skin.

The Science Behind
Our Products

Rejuran® uses c-PDRN® to encourage dramatic age-defying results for more radiant, youthful looking skin.

What is c-PDRN®?

c-PDRN® was developed by a team of Korean skincare and research scientists who previously discovered how to harness the body’s natural ability to repair and regenerate cells with PDRN-Polydeoxyribonucleotide, a powerful skin-renewing ingredient derived from naturally occurring marine DNA. PDRN is a proprietary and registered drug that possesses several qualities: tissue repair, anti-ischemic, and anti-inflammatory. PDRN was originally created for dermatologists as an injectable biostimulator to induce production of natural collagen. The revolutionary anti-aging ingredient became one of the most sought-after dermatological treatments in Asia and Europe.

c-PDRN® was developed for use in cosmetics to help improve the appearance of skin health.


The Power of Science and Nature

Real Results

Rejuran’s clinically proven ingredients and exclusive c-PDRN® technology bring you skincare with results you can see.

Baseline vs. Day 30

Female, Age 75

How it Works

c-PDRN® is a patented next-generation ingredient, technically known as Hydrolyzed DNA, the building blocks of life. As you age, your skin produces less collagen and cellular turnover slows from 28 days to as many as 50 days, resulting in dull, sagging, damaged skin. c-PDRN® helps improve the appearance of damaged skin, restoring the look of skin’s elasticity and firmness.

Why it Works

c-PDRN® molecules are 670 times smaller than human skin pores. This low molecular weight allows it to be more easily absorbed through topical skincare products for fast, effective results. Unlike ingredients with a high molecular weight that are poorly absorbed and sit on top of your skin, c-PDRN’s tiny molecules are readily absorbed for maximum benefit.

What c-PDRN® Does

Regenerate the Appearance of Skin

  • Delivers a brighter looking complexion, smoother skin, and improves the look of fine lines & wrinkles
  • Addresses dull, dry, flaky skin that can come with age and slowing cell regeneration

Improve the Look of Skin Elasticity

  • Helps improve the look of skin firmness, reducing the appearance of sagging and low skin elasticity

Promotes Skin Rejuvenation

  • Naturally occurring growth factor cell stimulators
  • Improves the look of fine lines & wrinkles
  • Improves the appearance of skin tone and texture
  • Improves the appearance of dark spots, skin blemishes, and facial scars

Skin Rejuvenation, Backed by Science

Click Here To See Science Journal Articles

Clinical Evaluation of the Trophic Effect of Polydeoxiribonucleotide (PDRN) in Patients Undergoing Skin Explants. A Pilot Study. P. Rubegni, Current Medical Research & Opinion (SCIE), 2001

Biorevitalization and Cosmetic Surgery of the Face: Synergies of Action. M. Cavallini, Unit of Plastic Surgery, Galeazzi Institute, 2004.03

Evaluation of the Efficacy of Polydeoxyribonucleotides in the Healing Process of Autologous Skin Graft Donor Sites: A Pilot Study. L. Valdatta, et al., Current Medical Research & Opinion (SCIE), 2004.05

Skin graft Donor Site and Use of Polydeoxyribonucleotide as a Treatment for Skin Regeneration: A Randomized, Controlled, Double-Blind, Clinical Trial. De Aloe, et al., WOUNDS (SCIE), 2004.08

Effects of Polydeoxyribonucleotide in the Treatment of Pressure Ulcers. J. Y. Kim, et al., Journal of Korean Medical Science (SCI), 2014.08

Novel Anti-Melanogenesis Properties of Polydeoxyribonucleotide, a Popular Wound Healing Booster. Tai Kyung Noh, et al., International Journal of Molecular Sciences (SCIE), 2016

Salvage of Unilateral Complete Ear Amputation with Continuous Local Hyperbaric Oxygen, Platelet-Rich Plasma and Polydeoxyribonucleotide without Micro-Revascularization. Seung Yong Song, et al., Archives of Plastic Surgery (-), 2017

Facial Annular Elastolytic Giant Cell Granuloma Treated With Pulsed Dye Laser and Intralesional Polydeoxyrironucleotide (CASE REPORT). Young Jae Kim, et al., Australasian Journal of Dermatology (SCIE), 2017

Polydeoxyribonucleotide and Hyaluronic Acid: Two Different Agents for Skin Regeneration. Vida Aesthetics, 2017

Facial Annular Elastolytic Giant Cell Granuloma Treated With Pulsed Dye Laser and Intralesional Polydeoxyrironucleotide. Young Jae Kim, et al., Australasian Journal of Dermatology (SCIE), 2017

Adjuvant Therapy for Revision Rhinoplasty of Contracted Nose Using Polydeoxyribonucleotide and Invasive Bipolar Radiofrequency. Tae Hwan Ahn, et al., IDEAS And INNOVATIONS, 2017

The Effect of Polydeoxyribonucleotide on Chronic Non-healing Wound of an Amputee: A Case Report (사지 절단환자의 만성적으로 치유되지 않은 상처에 대한 Polydeoxyribonucleotide의 효과 : 증례보고). 배하석 외, ANNALS OF REHABILITATION MEDICINE-ARM (ESCI), 2018

The Effects of Polydeoxyribonucleotide on Wound Healing and Tissue Regeneration: A Systematic Review of the Literature (상처치유와 조직재생에서 PDRN의 효과: 체계적 문헌고찰). Maria T Colangelo, Carlo Galli, Stefano Guizzardi, REGENERATIVE THERAPY (SCIE), 2020


Polydeoxyribonucleotide for the Improvement of a Hypertrophic Retracting Scar - An Interesting Case Report (비대성 흉터의 개선을 위한 PDRN의 응용). Magda Belmontesi, JOURNAL OF COSMETIC DERMATOLOGY (SCIE), 2020


Wound Healing is Accelerated by Agonists of Adenosine A2(Gas-linked) Receptors. M. Carmen Montesinos, et al., J. Exp. Med., 1997

Defibrotide in Combination With Granulocyte Colony-Stimulation Factor Significantly Enhances The Mobilization Of Primitive And Committed Peripheral Blood Progenitor Cells In Mice. Carmelo C-S., et al., Cancer Research (SCI), 2002.11

Adenosine A2A Receptor Agonists Promote More Rapid Wound Healing Than Recombinant Human Platelet-Derived Growth Factor (Becaplermin Gel). Cassandre Victor-Vega, et al., INFLAMMATION (SCI), 2002.02

Adenosine Promotes Wound Healing and Mediates Angiogenesis in Response to Tissue Injury Via Occupancy of A2A Receptors. M. Carmen Montesinos, et al., American Journal of Pathology (SCI), 2002.06

Development of Salmon Milt DNA/Salmon Collagen Composite for Wound Dressing. Shen, et al., JOURNAL OF MATERIALS SCIENCE - MATERIALS IN MEDICINE (SCIE), 2008

Polydeoxyribonucleotide Improves Angiogenesis and Wound Healing in Experimental Thermal Injury. Alessandra Bitto, et al., Crit Care Med, 2005

The Effect of Human Placenta Extract in a Wound Healing Model. Hong, et al., Annals of Plastic Surgery (SCI), 2010

The Wound Healing Effect of PDRN (polydeoxyribonucleotide) Material on Full Thickness Skin Defect in the Mouse (흰 쥐의 전층피부 결손에 대한 PDRN (polydeoxyribonucleotide) 제재의 창상치유 효과). Y. H. Kim, et al., 대한성형외과학회지(Journal of the Korean Society of Plastic and Reconstructive Surgeons), 2010.05

A Novel Composition For In Vitro and In Vivo Regeneration of Skin and Connective Tissues. L. Gennero, et al., Cell Biochemistry and Function (SCI), 2011.02

Polydeoxyribonucleotide restores Blood Flow in an Experimental Model of Ischemic Skin Flaps. F. Polito, et al., Journal of Vascular Surgery (SCI), 2012.02

Effectiveness of Polydeoxyribonucleotide (PDRN) Material on Murine Subcutaneous Laceration Wounds (피하층 열상 쥐모델에서 Polydeoxyribonucleotide (PDRN)가 봉합치료에 미치는 효과). J. Y. Kim, et al., 대한응급학회지(Journal of the Korean Society of Emergency Medicine), 2013.08

The Effects of Polydeoxyribonucleotide on the Survival of Random Pattern Skin Flaps in Rats. 청건일, Archives of Plastic Surgery, 2013.05

Wound Healing Effect of Polydeoxyribinucleotide(PDRN) Extracted from Domestic Salmon (국내산 연어 추출 Polydeoxyribonucleotide 재제의 창상 치유 효능). 이종훈, KSPRS International Beyond Beauty, 2014.11

저분자화된 Polydeoxynucleotide (PDRN)의 흰쥐에 대한 외과적 창상 치유 효과. 윤종국 외, Journal of the Society of Cosmetic Scientists of Korea, 2015.12

The Effect of Polydeoxyribonucleotide on Ischemic Rat Skin Flap Survival. W. J. Lee, et al., Annals of Plastic Surgery (SCI), 2015.05

Polydeoxyribonucleotide Improves Wound Healing of Fractional Laser Resurfacing in Rat Model. Mi Yu, et al., Journal of Cosmetic and Laser Therapy (SCIE), 2017.

Polydeoxyribonucleotide, an Adenosine-A2a Receptor Agonist, Preserves Blood Testis Barrier From Cadmium-Induced Injury. Francesco Squadrito, et al., Frontiers in Pharmacology (SCIE), 2017

L'activation Du Récepteur De L'adénosine Par Pdrn Améliore Le Remodelage Cutané Dans Un Modèle Expérimental De Dermatite De Type Psoriasis. M. Vaccaro, et al., Annales De Dermatologie Et De Venereologie (SCIE), 2017

Scar Prevention and Enhanced Wound Healing Induced by Polydeoxyribonucleotide in a Rat Incisional Wound-Healing Model. Ju Hee Lee, International Journal of Molecular Sciences, 2017

(러시아) ВЛИЯНИЕ ПОЛИНУКЛЕОТИДОВ НА СОДЕРЖАНИЕ МАКРОФАГОВ В ТКАНЯХ РЕГЕНЕРИРУЮЩЕЙ ИШЕМИЗИРОВАННОЙ РАНЫ
(영문번역) Influence Of Polynucleotides On The Content Of Macrophages In Tissue Of Regenerating Ishemized Waiting. Shapovalova E. Yu., et al., Modern Problems of Science and Education, 2017

An Effective Range Of Polydeoxyribonucleotides Is Critical For Wound Healing Quality
상처 치유의 질(Quality)에 대단히 중요한 PDRN의 효과 범위. Kyu-Hee Hwang, et al., Molecular Medicine Reports (SCIE), 2018

Comparison of Wound Healing Effects Between Oncorhynchus Keta –Derived Polydeoxyribonucleotide (PDRN) and Oncorhynchus Mykiss -Derived PDRN. Jong Hun Lee, et al., Archives of Craniofacial Surgery (-), 2018

Recent Advances in Scar Biology. Rei Ogawa (일본), International Journal of Molecular Sciences (SCIE), 2018

PDRN, a Biologic Agonist of The Adenosine A2a Receptor, Ameliorates Imiquimod-Induced Psoriasis Through Nf-Κb Pathway Inhibition and Wnt/Β-Catenin Signalling Modulation. Irrera N 외, EBIOMEDICINE (SCI-E), 2019

Effects of Human Placenta Extract (Laennec) on Ligament Healing in a Rodent Model. Eun Ho Shin, et al., Biological & Pharmaceutical Bulletin (SCI), 2019

PDRN, a Bioactive Natural Compound, Ameliorates Imiquimod‐Induced Psoriasis Through NF‐κB Pathway Inhibition and Wnt/β‐Catenin Signaling Modulation. Natasha Irrera, et al., International Journal of Molecular Sciences (SCI-E/ 4.183), 2020

Human Placental Laminin: Role In Neuronal Differentiation, Cell Adhesion and Proliferation
(인태반의 Laminin: 신경에서 분화, 세포 결합, 증식의 역할). Chaitali Mukherjee, et al., Journal of Biosciences (SCIE), 2020

Polydeoxyribonucleotides Enhance The Proliferation of Human Skin Fibroblasts: Involvement Of A2 Purinergic Receptor Subtypes. Thellung S., et al., Life Sciences (SCI), 1999.01

Effect of Polydeoxyribonucleotides on Human Fibroblasts in Primary Culture. P. SINI, et al., Cell Biochemistry and Function (SCI), 1999.06

Comparative Study of the Effects of Trophoblastin and Polydeoxyribonucleotide Preparations on Cultured Skin Fibroblast. O. G. Pleshkanyova, et al., Cell Technologies in Biology and Medicine (SCIE), 2007.07

Polydeoxyribonucleotide promotes Cyclobutane Pyrimidine Dimer Repair in UVB Exposed Dermal Fibroblasts. Silvana Belletti, et al., Photodermatol Photoimmunol Photomed (SCIE), 2007

Effects of Polydeoxyribonucleotides (PDRN) on Wound Healing: Electric Cell-Substrate Impedance Sensing (ECIS). Youngmi Koo, at al., Materials Science & Engineering C-Materials for Biological Applications (SCIE), 2016

Effect of Retinoic Acid on Proliferation of Human Umbilical Vein Endothelial Cells
(레티노산이 인간 제대정맥혈관내피세포의 확산에 미치는 영향), Han Gyu Cha, et al., Journal of Wound Management and Research (-), 2018

Polydeoxyribonucleotide Activates Mitochondrial Biogenesis but Reduces MMP-1 Activity and Melanin Biosynthesis in Cultured Skin Cells. Yeon-Ji Kim, et al., Applied Biochemistry and Biotechnology, 2019